JMCB Symposium 2019:
The Legend of p53 vs. Cancer

JMCB Symposium 2019:
The Legend of p53 vs. Cancer

10−12 May 2019, Hangzhou, China


10−12 May 2019, Hangzhou, China

Register now Program

Program

At a glance

Venue: Auditorium, Shangri-La Hotel, 78 Beishan Road, Hangzhou

Friday 10 May (D1)

14:00-17:00 Registration
17:00-21:00 The Night of p53
Welcome & Opening
Keynote lecture
Open Discussion: The Future of p53 Research
Reception (all attendees)

Saturday 11 May (D2)

08:30-12:10 Session I: Gene Regulation & Epigenetics  
Keynote & Session talks
12:10-14:00 Lunch (3rd floor) & Posters (1st floor)
14:00-18:00 Session II: The Fourth Decade of p53  
Keynote & Session talks
18:30-21:00 Banquet (Invitees only)

Sunday 12 May (D3)

08:30-12:30 Session III: The p53 Network  
Keynote & Session talks
12:30-14:00 Lunch (3rd floor) & Posters (1st floor)
14:00-16:10 Session IV: p53 and Oncogenes in Translational Cancer
Session/Industry talks
16:10-16:30 Wrap Up & Closing

Friday 10 May 2019

17:00-21:00    The Night of p53

Chaired by Hua Lu

17:00-17:30 Hua Lu Tulane University, USA 
Welcome & Introduction
17:30-17:40 Jiarui Wu Institute of Biochemistry and Cell Biology, CAS, China
Opening Remarks 
17:40-17:50 Hua Lu Tulane University, USA 
Introduction for 40th anniversary of p53
17:50-18:30 Arnold J. Levine Institute for Advanced Study, USA 
Keynote: Discovery of p53
18:30-19:10 Carol Prives Columbia University, USA
Keynote: Roles of p53 and Mdm2 in regulation of lipid metabolism
19:10-19:30 Open Discussion: The Future of p53 Research 
Arnold J. Levine Institute for Advanced Study, USA 
Guillermina Lozano MD Anderson Cancer Institute, USA 
Carol Prives Columbia University, USA 
Robert G. Roeder The Rockefeller University, USA 
(Facilitated by Hua Lu and Wei Gu)

  Saturday 11 May 2019

08:30-12:10 Session I: Gene Regulation & Epigenetics

Chair: Wei Gu

08:30-08:45 Wei Gu Columbia University, USA
Introduction for 50th anniversary of RNA Polymerases I, II, III
08:45-09:25 Robert G. Roeder The Rockefeller University, USA 
Keynote: 50+ years of transcription: complexities and mechanisms unforeseen 
09:25-10:05 Yi Zhang Harvard University, USA 
Keynote: A new mechanism of genomic imprinting and its role in development & SCNT reprogramming  
10:05-10:25 Guohong Li Institute of Biophysics, CAS, China 
Title: Structure and functions of higher-order chromatin structures in gene regulation and epigenetic inheritance 
10:25-10:50 BREAK

Co-chairs: Yi Zhang & Xin-Hua Feng

10:50-11:30 Guoliang Xu Institute of Biochemistry and Cell Biology, CAS; Fudan University School of Medicine, China 
Keynote: Enzymatic DNA methylation and oxidation in developmental control 
11:30-11:50 Wei-Guo Zhu Shenzhen University School of Medicine, China 
Title: SIRT7 plays essential roles in stress responses and activation of p53 
11:50-12:10 David M. Gilbert Florida State University, USA 
Title: Developmental control of replication timing and chromosome architecture 

13:20-14:00 Poster Session

14:00-18:00 Session II: The Fourth Decade of p53

Co-chairs: Guillermina Lozano & Xin Lu

14:00-14:40 Wei Gu Columbia University, USA
Keynote: Dissecting the roles of p53 acetylation in transcription regulation and tumor suppression
14:40-15:00 Xin Lu Ludwig Institute for Cancer Research, University of Oxford, UK
Title: Structural insights into p53‒iASPP interactions: target selectivity and the oncoprotein HPV E6 connection
15:00-15:20 Ygal Haupt Peter MacCallum Cancer Centre, Australia
Title: Targeting MDM4 alone, or in combination with p53 reactivation, in hormone-related cancers
15:20-15:40 Jiandong Chen Moffitt Cancer Center, USA
Title: p53 N-terminus regulates core domain DNA binding
15:40-16:00 BREAK

Co-chairs: Sue Haupt & Yanping Zhang

16:00-16:20 Giannino Del Sal University of Trieste & IFOM, Italy 
Title: Mutant p53 shapes the Golgi structure and drives a prometastatic secretome 
16:20-16:40 Wenwei Hu Rutgers Cancer Institute of New Jersey, Rutgers University, USA 
Title: Gain-of-function mutant p53 activates small GTPase Rac1 signaling to promote tumor progression 
16:40-17:00 Gareth L. Bond Ludwig Institute for Cancer Research, Oxford University, UK 
Title: Inherited and somatic genetic variants in the p53 pathway interact to affect cancer risk and progression 
17:00-17:20 Jinrong Peng Zhejiang University, China 
Title: p53, p53 isoforms Δ113p53/Δ133p53 and their turnover in the nucleous by the Def-Capn3 protein degradation pathway 
17:20-17:40 Zhi-Xiong Xiao Sichuan University, China 
Title: p53-R273H upregulates EGFR expression and inhibition of KLF6 to promote tumor metastasis 
17:40-18:00 Peng Jiang Tsinghua University, China 
Title: Exploring the role of p53 in cancer metabolism

Sunday 12 May 2019

08:30-12:30 Session III: The p53 Network

Co-chairs: Carol Prives & Jiandong Chen

08:30-09:10 Guillermina Lozano The University of Texas MD Anderson Cancer Institute, USA 
Keynote: Mutant p53 activities in a somatic model of breast cancer 
09:10-09:30 Yanping Zhang The University of North Carolina at Chapel Hill, USA 
Title: Regulation of p53 protein expression by MDMX 
09:30-09:50 Hua Lu Tulane University, USA 
Title: Regulation of the ribosomal stress‒MDM2‒p53 pathway 
09:50-10:10 Xin-Hua Feng Zhejiang University, China 
Title: Interactive oncogene‒tumor suppressor signaling in cancer  
10:10-10:30 BREAK

Co-chairs: Giannino Del Sal & Wenwei Hu

10:30-10:50 Zhi-Min Yuan Harvard University, USA 
Title: A novel function of p53 in the liver 
10:50-11:10 Yang Xu University of California, San Diego, USA 
Title: The complex roles of p53 in metabolism 
11:10-11:30 Zhaohui Feng Rutgers Cancer Institute of New Jersey, Rutgers University, USA 
Title: p53 target E3 ubiquitin ligase Parkin inhibits glycolysis and cancer metastasis
11:30-11:50 Hai Jiang Institute of Biochemistry and Cell Biology, CAS, China 
Title: Defining relative mutational difficulty to understand the functionality of p53 mutations  
11:50-12:10 Bin-Bing Zhou Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, China
Title: TP53 mutations drive clonal evolution during treatment of relapsed childhood ALL
12:10-12:30 Xiang Zhou Shanghai Cancer Center and Institutes of Biomedical Sciences of Fudan University, China
Title: Ubiquitin ligase TRIM71 suppresses ovarian tumorigenesis by degrading mutant p53

13:20-14:00 Poster Session

14:00-16:10 Session IV: p53 and Oncogenes in Translational Cancer

Co-chairs: Shaomeng Wang & Ruiwen Zhang

14:00-14:20 Shaomeng Wang University of Michigan, USA 
Title: Inducing MDM2 degradation as a cancer therapeutic strategy 
14:20-14:40 Ruiewen Zhang University of Houston, USA 
Title: One stone two birds: targeting MDM2 oncogene and inflammation pathways for cancer therapy 
14:40-15:00 Xin-Yuan Fu Sichuan University, West China Hospital, China 
Title: The JAK‒STAT pathway to Peri-Genetics and clinical applications 
15:00-15:20 Kanaga Sabapathy National Cancer Centre Singapore, Singapore 
Title: Targeting p53 for cancer cure and prevention 
15:20-15:40 Min Lu Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China 
Title: Small-molecule compounds fully rescue a batch of structural mutant p53 with solved atom-level mechanism 
15:40-15:55 Weikang Tao Jiangsu Hengrui Medicine Co., Ltd, China 
Title: Cancer therapy R&D in China from a global view
15:55-16:10 Dajun Yang Ascentage Pharma (Suzhou) Co., Ltd, China 
Title: MDM2 inhibitor APG-115 sensitizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment

16:10-16:30 Wrap Up & Closing by Guillermina Lozano

Posters (11 & 12 May 13:20-14:00)

No. Title
P-1 Overexpression of Brf1 via interaction with ERα is associated with prognosis of hormone treatment in breast cancer
P-2 Exacerbated mutant p53 co-aggregation drives tumor cellular fitness in environmental stress
P-3 Histone deacetylase 2 is involved in DNA damage-mediated cell death of human osteosarcoma cells through stimulation of the ATM/p53 pathway
P-4 Reactivation of mutant p53 by natural product buxus alkaloids
P-5 Mechnism of GANAB promotes epithelial-to-mesenchymal transition of bladder cancer revealed by single-cell sequencing
P-6 Preventive drug treatment targeting glioma initiating cells prolongs tumor-free survival in a p53 hotspot mutation-driven de novo glioblastoma mouse model
P-7 Using a novel mutant p53 protein level reporter mouse model to delineate the early transformation process of mutant-p53-accumulating cells during lymphomagenesis
P-8 Oncogenic HRasG12V cooperates with p53N236S mutant to escape oncogene-induced cellular senescence via PGC-1α
P-9 p53 isoform Δ113p53 promotes zebrafish heart regeneration via maintaining ROS homeostasis
P-10 H2B monoubiquitination is a key epigenetic regulator of ferroptosis and is regulated by p53
P-11 A novel inducible mutagenesis screen enables to isolate and clone both embryonic and adult zebrafish mutants
P-12 Ribosome biogenesis factor Bms1-like is essential for liver development in zebrafish
P-13 Zebrafish nucleolar ribosomal protein Rcl1 involving in site 1 cleavage in 5’-external transcribed spacer of pre-rRNAs affects liver development
P-14 Ubiquitin ligase TRIM71 suppresses ovarian tumorigenesis by degrading mutant p53
P-15 Dual regulation of p53 by the ribosome maturation factor SBDS
P-16 The transcriptional activity rescue spectrum for mutant p53-rescuing compounds AS-001, L-902, GA, and SG
P-17 DNA-damaging agents boost tumor-suppressive function of chemically rescued mutant p53
P-18 TP53 mutations drive clonal evolution during treatment of relapsed p53 mutant childhood ALL